Kai'Sa

Ranged AD SupportPrimaryLast WhisperRed BuffBlue Buff

16 missiles sprayed across every enemy within 2 hexes of her target is the best spread pattern in the set for landing sunder, wound and burn, with a takedown mana loop keeping casts frequent. For supports whose ability is a long volley: Last Whisper and Red Buff still spread Sunder, Burn and Wound, while Blue Buff refunds the casts that hit-based mana items cannot fuel.

Ranged AD CarrySolidBlue BuffInfinity EdgeDeathblade

Her 16-missile cluster is a channel volley, so attack speed and hit-based mana are wasted; her takedown mana plus Blue Buff refund the next cluster.