Karma

Ranged AP CarryPrimarySpear of ShojinRabadon's DeathcapJeweled Gauntlet

A massive Ability-Power-scaling nuke split between the target and the two closest enemies, with the target taking an extra chunk on top; a 4-cost nuker on a fast 10/55 loop that focuses down priority targets.

Ranged AP SupportSolidVoid StaffRed BuffSpear of Shojin

Every cast clips the two enemies nearest her target, so shred and burn ride along on an already strong nuke. For supports with quick casts: Void Staff spreads Shred, Red Buff adds Burn and Wound, and Spear of Shojin accelerates the short casts that deliver them.